Research Areas
Our research is dedicated to exploring the complex world of RNA and DNA interactions in bacteria, focusing on the regulatory processes governing protein synthesis.
RNA-RNA Interactome
Exploring the network of small RNA (sRNA) and messenger RNA (mRNA) interactions inside bacterial cells. We are translating this to single-cell TRIC-seq to identify RNA-based regulation in transcriptionally distinct populations.
Membrane-DNA Interactions
We investigate membrane-DNA/RNA interactions in bacterial cells to uncover their role in DNA replication and membrane-protein insertion in the context of Transertion.
Membrane BiologyUnorthodox RNA & DNA Interactions
Dissecting non-canonical regulatory pathways. We capture interactions inside bacterial cells that reveal fundamentally new, unconventional modes of gene regulation.
DiscoveryPlant-Bacteria RNA-RNA Regulation
Elucidating the dynamics of plant-microbe symbiosis by mapping RNA-RNA regulatory interactions in root nodules.
Symbiosis StudyGenerative AI Minibinders
Applying generative AI to design synthetic minibinders targeting bacterial cell receptors and specific RNAs for therapeutic and diagnostic interventions.
AI DesignDNA-RNA Interactome (BRAID-seq)
Developing BRAID-seq to map high-resolution DNA-RNA interactions transcriptome-wide in bacteria, enabling deep insights into transcriptional regulation (in-progress).
Method Development